Abstract
Background: Chlorfenapyr is a widely used insecticide worldwide for farming. However, chlorfenapyr intoxication with organic brain lesion has never been reported. Case report: A 49-year-old man attempted suicide by ingesting 200 ml of Chlorfenapyr. He suffered from severe diaphoresis with a sustained high fever. Ten days after chlorfenapyr poisoning, he developed altered mentality. Brain Magnetic resonance imaging (MRI) showed extensive bilateral involvement of the white matter. Conclusion: We presumed Chlorfenapyr or its metabolite can induced delayed neurotoxicity in the central nervous system. We report herein a case of Chlorfenapyr intoxication with brain MRI findings.
Highlights
Chlorfenapyr [4-bromo-2-(4-chlorophenyl)-1-(ethoxymethl)-5(trifluoromethyl)-1H-pyrrole-3-carbonitrile] is widely used pesticide to control cotton worms or insects around the world. [1,2] Chlorfenapyr interferes with mitochondrial oxidative phosphorylation, resulting in disruption of ATP production and eventual cellular death [2]
We present a case of chlorfenapyr poisoning with central nervous system involvement
Patients with chlorfenapyr intoxication should be carefully observed for a delayed mental status up to a couple of weeks after ingestion
Summary
Chlorfenapyr [4-bromo-2-(4-chlorophenyl)-1-(ethoxymethl)-5(trifluoromethyl)-1H-pyrrole-3-carbonitrile] is widely used pesticide to control cotton worms or insects around the world. [1,2] Chlorfenapyr interferes with mitochondrial oxidative phosphorylation, resulting in disruption of ATP production and eventual cellular death [2]. [1,2] Chlorfenapyr interferes with mitochondrial oxidative phosphorylation, resulting in disruption of ATP production and eventual cellular death [2]. We present a case of chlorfenapyr poisoning with central nervous system involvement. His vital signs on arrival were as follows: blood pressure 120/70 mmHg, heart rate; 60/minute, respiratory rate; 20/minute and body temperature; 36°C.
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