A case of CD8+ small/medium-sized pleomorphic T-cell lymphoma: clinical and histopathological differential diagnosis

Abstract

Funding sources: none. Conflicts of interest: none declared. Dear Editor, CD8+ lymphoid proliferation is a rare type of cutaneous T‐cell lymphoma.1 Recently, CD8+ lymphoid proliferations that usually present with solitary, slow‐growing nodules on the face or ear, and which resolve after treatment, have raised the possibility of a distinct entity, although the prognostic influence of the CD8 phenotype is still unclear. Irrespective of the histopathological appearance suggesting a high‐grade lymphoma in some cases, clinical behaviour should be the main basis for the determination of treatment.2 3 A 60‐year‐old female patient was admitted with the complaint of progressively increasing red and swollen lesions on her face. Histopathological examination of the initial biopsy, performed 6 years previously, had been compatible with rosacea; a partial regression occurred with rosacea treatments. However, more prominent lesions recurred at almost the same sites after nearly 1 year. A second biopsy exhibited ‘perifollicular lymphoid infiltration’. The patient had no drug history. A partial regression has been noticed with intralesional steroid injections.