Abstract
Introduction: Cavernous sinus thrombosis (CST) is a rare manifestation of cerebral venous thrombosis. We herein describe the first case of CST associated with the oral microbes (Dialister pneumosintes, Slackia exigua and Prevotella baroniae). Case presentation: An 82‐year‐old previously self‐supported Japanese woman presented with acute onset of impaired consciousness. Computed tomography revealed intracranial haemorrhage complicated with CST. D. pneumosintes, Slackia exigua and P. baroniae were cultivated from two sets of blood cultures and were identified with 16S rRNA sequencing. The patient was successfully discharged after ampicillin–sulbactam treatment, which was performed soon after admission. Conclusion: To our knowledge, this is the first description of CST caused by D. pneumosintes, Slackia exigua and P. baroniae. CST should be considered in cases of unusual distribution of cerebral haemorrhage.
Highlights
Cavernous sinus thrombosis (CST) is a rare manifestation of cerebral venous thrombosis
Staphylococcus aureus is isolated in Abbreviations: CST, cavernous sinus thrombosis; Computed tomography (CT), computed tomography
In this case we identified three anaerobes (D. pneumosintes, S. exigua and P. baroniae), all of are oral microbes whose molecular features were established recently (Doan et al, 2000; Downes et al, 2005; Moore & Moore, 1994; Wade et al, 1999)
Summary
Cavernous sinus thrombosis (CST) is a rare manifestation of cerebral venous thrombosis. We report a case of CST caused by Dialister pneumosintes, Slackia exigua and Prevotella baroniae, which are oral anaerobes that we determined using 16S rRNA sequencing. Matsumura H. and others morning of the day of admission without preceding symptoms, but was drowsy and unable to locate the toilet at home when her son returned in the afternoon Her consciousness rapidly deteriorated during transportation and she had become unresponsive soon after arriving at our emergency department. Two sets of blood cultures were incubated with the BacT/ ALERT system (bioMerieux), and positive signals were obtained in both of the anaerobic bottles after 78 and 86 h. We performed sequence analysis for the Gram-negative rod initially considered as B. uniformis, and this was genetically classified as P. baroniae based on GenBank database searches (99.8 % match; 822/824 bp compared with P. baroniae strain E9.33, GenBank accession number AY840553). Owing to the sequelae of cerebral haemorrhage, she needed physical assistance, and her physical status at discharge was recorded as Grade 4 based on the modified Rankin Scale
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
