Abstract
We describe a case of breakthrough Candida parapsilosis fungemia in an 80-year-old woman with pyoderma gangrenosum and rheumatoid arthritis. C. parapsilosis was detected in blood culture while the patient was treated with micafungin for a Candida glabrata bloodstream infection. The breakthrough infection was successfully treated with liposomal amphotericin B.
Highlights
Candida spp. are the fourth leading cause of catheter-related bloodstream infections (BSIs) [1]
Micafungin was switched to liposomal amphotericin B (3 mg/kg/ day), as this medication is effective for both C. glabrata and C. parapsilosis
We encountered a case of breakthrough C. parapsilosis fungemia in a patient who was treated with micafungin for a C. glabrata BSI
Summary
Candida spp. are the fourth leading cause of catheter-related bloodstream infections (BSIs) [1]. We report an 80-yearold woman with pyoderma gangrenosum and rheumatoid arthritis in whom a breakthrough infection of C. parapsilosis was detected in blood culture during micafungin therapy for a C. glabrata bloodstream infection. The patient was treated with prednisolone 40 mg/day for pyoderma gangrenosum; tazobactam/piperacillin was administered since an infection of the ulcers was suspected.
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