Abstract
Dedifferentiated liposarcoma is recognized as a type of liposarcoma that usually occurs concomitantly with the well-differentiated type. In this report, we discuss the case of a 65-year-old man who developed a dedifferentiated liposarcoma with second recurrence of an atypical lipomatous tumor. The patient first presented to us with an atypical lipomatous tumor of the right elbow for which he underwent a marginal resection. After five months, the patient experienced tumor recurrence for which he underwent another extended resection. Approximately 10 months following this surgery, the tumor recurred a second time for which he underwent another extended resection. Histopathological analysis of the second recurring tumor revealed a dedifferentiated liposarcoma. So far, two years following this resection, recurrence has not been observed. This is the first case of an atypical lipomatous tumor that dedifferentiated after the additional extended resection.
Highlights
A liposarcoma is a malignant mesenchymal tumor that can present as an atypical lipomatous tumor, welldifferentiated liposarcoma, dedifferentiated liposarcoma, myxoid liposarcoma, and pleomorphic liposarcoma [1]
In 1979, Evans suggested that a dedifferentiated liposarcoma was similar to a differentiated adipose sarcoma [2], which frequently occurs in limbs and the retroperitoneum and is more likely to affect patients aged 40 to 60 years [1, 3]
We describe a very rare case of dedifferentiated liposarcoma that occurred in a patient following additional resection for an atypical lipomatous tumor
Summary
A liposarcoma is a malignant mesenchymal tumor that can present as an atypical lipomatous tumor, welldifferentiated liposarcoma, dedifferentiated liposarcoma, myxoid liposarcoma, and pleomorphic liposarcoma [1]. No cases of atypical lipomatous tumor that dedifferentiated with recurrence after additional extended resection have been reported. We describe a very rare case of dedifferentiated liposarcoma that occurred in a patient following additional resection for an atypical lipomatous tumor. Magnetic resonance imaging (MRI) shows the right elbow after recurrence with sagittal (A) and coronal sections (B). One year following this surgery, the tumor recurred as indicated on MRI imaging (Figure 3A, 3B). We treated the patient by performing an extended resection This time, the histological analysis revealed a proliferation of atypical lipomatous cells and high-grade spindle cells (Figure 3C). Magnetic resonance imaging (MRI) features of the right elbow after the second recurrence with sagittal (A) and coronal sections (B). Two years have passed, and no recurrence has been observed
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