Abstract
We experienced a case of apocrine carcinoma of the breast with a predominant intraductal component. The complaint patient was seen at the hospital because of nipple discharge. Cytology of the nipple discharge suggested ductal carcinoma of comedo type. The reddness, thickness, and irregularity of the ductal wall were observed by a duct endoscopy. Carcinoembryonic antigen (CEA) in the nipple discharge was 1000ng/ml. Immunohistochemical staining for CEA and anti-gross cystic disease fluid protein 15 (GCDFP-15) was positive. In a review of 75 cases of apocrine carcinoma of the breast previously reported in Japan, three cases had nipple discharge. Of four cases of apocrine carcinoma including ours, two cases had an invasive microcarcinoma and another two cases, non-invasive carcinoma, and all carcinomas mainly extended within the lactiferous duct. So long as endoscopic findings of the duct are concerned, this is the first report of apocrine carcinoma of the breast.
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