Abstract
We report herein on a case of undifferentiated carcinoma of the thyroid with a high serum G-CSF level. A 78-year-old woman was referred to hospital in respiratory discomfort that caused by large neck mass. A cytological examination from an aspiration biopsy disclosed papillary carcinoma of the thyroid. CT and MRI examinations revealed thyroid carcinoma with laryngeal infiltration and lung metastasis. We diagnosed it as papillary carcinoma of the thyroid (T4aN1aM1 Stage IVc) and suggested surgery with radiation therapy. However, she and her family were not expecting treatment, so we performed only a tracheostomy. Four years later, she was admitted to our hospital because of a rapidly enlarging tumor, anorexia and general malaise. She died a month later after admission. Marked elevation of the number of leukocytes to 178,900/mm3 was observed during the clinical course, and an increase in the G-CSF level (139 pg/dl) was demonstrated in the serum. We discuss the clinical course and prognosis of this tumor based on our case with reference to the literature.
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