Abstract
Background: Although Alzheimer’s disease (AD) has been intensively investigated for many years, the effective treatments are largely missing. Commonly used conventional therapy, such as cholinesterase inhibitors (ChEI) and N-methyl D-asparate receptor antagonist, have been generally considered as having symptom-relieving rather than disease-modifying effects. Thus, how to improve cognitive function beyond such effect & time limitations has become a serious challenge. Aim: In order to solve this challenge, a sequential therapy with the integration of conventional therapy and herbal therapy was applied to AD patients. Careful clinical observation was conducted in our outpatient setting. Case Presentation: A case of probable AD received the sequential therapy has achieved relative stable cognition and overall status in eight years. Conclusion: During the treatment of this AD case in eight years, sequential therapy showed great potential in stabilizing and improving cognition and overall status. Well designed preclinical and clinical studies are needed to investigate the efficacy of sequential therapy for AD and other type of dementia.
Highlights
Alzheimer’s disease (AD), the most common cause of dementia in the elderly, will dramatically increase in prevalence during the process of worldwide demographic ageing
Well designed preclinical and clinical studies are needed to investigate the efficacy of sequential therapy for AD and other type of dementia
AD has been intensively investigated for many years, the effective treatments are largely missing
Summary
Alzheimer’s disease (AD), the most common cause of dementia in the elderly, will dramatically increase in prevalence during the process of worldwide demographic ageing. It is an irreversible, progressive neurodegenerative disease, which gradually destroys memory, thinking ability, and eventually the ability to carry out the simplest tasks like eating. AD has been intensively investigated for many years, the effective treatments are largely missing. Used medications, such as cholinesterase inhibitors (ChEI) and N-methyl D-aspartate receptor antagonistara generally considered as symptom-relieving rather than disease-modifying effects [1] [2]. We report a case of probable AD received a sequential therapy, which combined ChEI and herbal medicines, has achieved a significant improvement in eight years of treatment
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