Abstract
A case of advanced multiple hepatocellular carcinomas (HCC) with portal vein tumor thrombosis successfully treated by oral tegafur/uracil is reported. A 69-year-old Japanese woman with advanced HCC with tumor thrombosis underwent transcatheter arterial infusion chemotherapy in April 2001. However, 1 year later, the patient experieced a recurrence with advanced multiple HCC with portal vein tumor thrombosis and ascites. Treatment with oral tegafur/uracil was started in May 2002 and resulted in the partial response of liver tumors and the complete improvement of ascites. She remained in good health for about 6 years. This case strongly suggests that oral tegafur/uracil is an effective treatment for some cases of advanced HCC with portal vein tumor thrombosis.
Highlights
Various treatment modalities, such as transcatheter arterial chemoembolization (TACE), percutaneous ethanol injection therapy (PEIT), and radiofrequency ablation (RFA) have been recently developed and are used worldwide to treat patients with hepatocellular carcinoma (HCC) [1,2,3,4]
A case of advanced multiple hepatocellular carcinomas (HCC) with portal vein tumor thrombosis successfully treated by oral tegafur/uracil is reported
She remained in good health for about 6 years. This case strongly suggests that oral tegafur/uracil is an effective treatment for some cases of advanced HCC with portal vein tumor thrombosis
Summary
Various treatment modalities, such as transcatheter arterial chemoembolization (TACE), percutaneous ethanol injection therapy (PEIT), and radiofrequency ablation (RFA) have been recently developed and are used worldwide to treat patients with hepatocellular carcinoma (HCC) [1,2,3,4]. It has been reported that patients with multiple HCCs with tumor thrombosis in the major portal branches were successfully treated with intraarterial 5-fluorouracil perfusion chemotherapy combined with subcutaneous interferon-alpha administration [5,6]. Such combination therapy may be a promising treatment modality for advanced HCC with tumor thrombosis. The prognosis of advanced HCC with tumor thrombosis (VP4) is still unsatisfactory. A rare case of advanced multiple HCCs with portal vein thrombosis (VP4) that was successfully treated by oral tegafur/uracil Japan) and had a good prognosis, with survival for more than 5 years, is reported
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