Abstract
An operated case of esophageal which was successfully treated with preoperative CDDP-5Fu regimen is reported, together with a review of the literature. A 67-year-old woman came to the hospital because of epigastralgia. On upper endoscopic examination, an esophageal cancer Type 2 was found at the abdominal esophagus (Ea). Biopsy of the tumor revealed moderately differentiated squamous cell carcinoma. Preoperative chemotherapy was started with 70mg/m2 of CDDP on the day first followed by 800mg/m2 of 5-Fu for consecutive 3 days. After the regimen upper gastrointestinal series and endoscopy revealed a slight decrease in tumor size but the response was judged no change. The tumor invaded the muscularis propria on endoscopic ultrasonography. On 18th day after preorerative chemotherapy right thoracotomy, lararotomy, and intrathoracic anastomosis were performed. Gross examination of the tumor showed MoPloAoNo. Histopathologicaly many foreign body giant cells were seen in the submucosal and subserosal layers, but no cancer cell was detected. The effect of this chemotherapy corresponded to Ef3 in the histologic criteria for the effect of anticancer chemotherapy. In additional 15 cases which wer done chemotherapy on our protocal, 2 cases corresponded to Ef2. Further examination of this chemotherapy would be also necessary in metastasized lesions.
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