A Case of Acute Renal Failure Following Ethylene Glycol Intoxication in a Dog

Abstract

The manuscript describes a clinical case of severe oligoanuric acute renal failure in a young dog following ethylene glycol intoxication. Significant deviations were established in urinary renal markers and blood biochemical parameters: severe azotemia, hypocalcaemia, hyperphosphataemia, hyperkalaemia and metabolic acidosis. The ultrasound renal findings demonstrated increased renal cortex echogenicity the typical for ethylene glycol intoxication, with a characteristic halo sign around the medulla. Electrocardiography showed a progressive decrease in amplitudes of P and R peaks, increased sharp edged repolarisation T wave. The performed symptomatic therapy did not lead to favourable outcome due to delayed intervention by the owner and non-administered antidotal therapy. The histopathological finding was consisted in degeneration, necrosis, desquamation of kidney epithelial cells, dilated tubules and multiple calcium oxalate deposits. The described changes, in our opinion, are relevant and could be used for diagnostics of the studied pathology.