Abstract
ObjectiveTo evaluate the association between mood and anxiety disorders in Hashimoto disease and Euthyroid Goitre in a case control study.MethodsCases included 19 subjects with Hashimoto disease in euthyroid phase, 19 subjects with euthyroid goitre, 2 control groups each of 76 subjects matched (4/1) according to age and sex drawn from the data base of a community based sample. Psychiatric diagnoses were formulated using the International Composite Diagnostic Interview Simplified, according to DSM-IV criteria. All subjects underwent a complete thyroid evaluation including physical examination, thyroid echography and measure of serum free T4 (FT4), free T3 (FT3), thyroid-stimulating hormone (TSH) and anti-thyroid peroxidase autoantibodies (anti-TPO). Results: Subjects with Hashimoto disease showed higher frequencies of lifetime Depressive Episode (OR = 6.6, C.L. 95% 1.2–25.7), Generalized Anxiety Disorders (OR = 4,9 Cl 95% 1.5–25.4) and Social Phobia (OR = 20.0, CL 95% 2.3–153.3) whilst no differences were found between subjects with goitre and controls.ConclusionThe study seems to confirm that risk for depressive disorders in subjects with thyroiditis is independent of the thyroid function detected by routine tests and indicates that not only mood but also anxiety disorders may be associated with Hashimoto disease.
Highlights
Clinical and epidemiological studies seem to indicate that an association between high levels of thyroid autoantibodies may be implicated in the increased frequencies of mood disorders observed in thyroid disease, independently of impairment of thyroid function [1,2,3]
Clinical Practice and Epidemiology in Mental Health 2005, 1:23 http://www.cpementalhealth.com/content/1/1/23 ried out by our group suggested a possible role of thyroid autoimmunity in the association between celiac disease and panic disorder and major depressive disorder [4]
The aim of the present study was to compare 2 clinical samples of subjects, one with Hashimoto disease and the second with euthyroid goitre versus controls drown from a community sample, in order to clarify whether the association of mood and anxiety disorder in Hashimoto disease is evident prior to impairment of thyroid dysfunction
Summary
Clinical and epidemiological studies seem to indicate that an association between high levels of thyroid autoantibodies may be implicated in the increased frequencies of mood disorders observed in thyroid disease, independently of impairment of thyroid function [1,2,3]. Clinical Practice and Epidemiology in Mental Health 2005, 1:23 http://www.cpementalhealth.com/content/1/1/23 ried out by our group suggested a possible role of thyroid autoimmunity in the association between celiac disease and panic disorder and major depressive disorder [4]. The aim of the present study was to compare 2 clinical samples of subjects, one with Hashimoto disease (in euthyroid phase) and the second with euthyroid goitre versus controls drown from a community sample, in order to clarify whether the association of mood and anxiety disorder in Hashimoto disease is evident prior to impairment of thyroid dysfunction
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Clinical Practice and Epidemiology in Mental Health
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
