A Case-Control Study of Serum and Tissue Catalase among Morphological Variants of Vitiligo.

Abstract

Role of oxidative stress in the pathogenesis of vitiligo. Estimation of serum and tissue catalase levels in morphological variants of vitiligo. A prospective case-control study was conducted in the outpatient department of Dermatology in Safdarjung hospital. We estimated levels of serum and tissue catalase in 30 vitiligo patients and 30 matched healthy controls. The data analysis was done in Statistical Package for Social Sciences (SPSS) version 21.0. Normality of data was tested by Kolmogorov-Smirnov test. Serum and tissue catalase was lower in vitiligo patients than controls. Serum catalase was lowest in vulgaris type, whereas in the acrofacial type had lowest tissue catalase levels. Vitiligo patients have a generalized oxidative stress functioning at a higher pace as seen with decreased serum and tissue CAT which can well be taken as a marker of active disease and they can be helped with topical pseudoCAT preparations.