Abstract

It is not often that one is invited to remember one's professional experience and if one does so in the course of conversation, a glazed look soon afflicts the recipient of such reminiscences. When I started medicine, methotrexate had just been shown to induce temporary remission in childhood leukaemia. Surgery and radiotherapy for Wilms' tumour had resulted in a few long-term survivors and these children acted as a beacon of hope. Admittedly, some adult patients had relief of symptoms of Hodgkin's disease from the use of nitrogen mustard, but the sequential use of alkylating agents and vinblastine was not curative.

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