Abstract
Organic Chemistry Adipic acid and its esters are manufactured on a massive scale, primarily to produce nylon. However, the standard route requires large quantities of corrosive nitric acid. J. Yang et al. present an efficient alternative route whereby a palladium catalyst adds carbon monoxide to each end of butadiene (see the Perspective by Schaub). Both reactants are available at commodity scale, and the reaction produces no by-products. An optimized bidentate phosphine ligand bearing a pyridine substituent for proton shuttling proved key to attaining the necessary selectivity. Science , this issue p. [1514][1]; see also p. [1448][2] [1]: /lookup/doi/10.1126/science.aaz1293 [2]: /lookup/doi/10.1126/science.aay0479
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