Abstract
A nanostructured immunosensor based on carbon nanotubes supported by a conductive polymer film was developed for detection of cardiac Troponin T (cTnT), an important cardiac marker for acute myocardial infarction. Carboxylated carbon nanotubes were covalently bound to the electrode surface via polyethyleneimine. The functionalized nanostructured surface was used to bind anti-cTnT monoclonal antibodies. Stepwise modification of the electrode was characterized by cyclic voltammetry studies. The immunosensor achieved a low limit of detection (0.033ngmL−1) and a linear range between 0.1 and 10ngmL−1 cTnT), significant for acute myocardial infarction diagnosis. Good reproducibility and repeatability were obtained by the proposed immunosensor supported by a coefficient of variation of 3.7% and 2.6%, respectively.
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