Abstract
In this edge article we report the preparation of a supramolecular carbohydrate hydrogel containing cyclodextrin vesicles as 3D junctions. A cellulose polymer is randomly modified with hydrophobic side groups that act as guests for the cyclodextrin hosts on the surface of the vesicles. Hence, the vesicles interconnect the polymer chains into a three-dimensional network and act as multivalent linkages. The resulting gel shows significant shear-thinning and self-healing properties, which make it highly suitable for applications that require injectability. Furthermore, SAXS and cryo-TEM measurements indicate that intact vesicles are present in the gel matrix.
Highlights
Hydrogels are biomimetic materials considering their porous structure with high water content and their viscoelastic properties similar to human tissue.[1,2,3,4,5]
The development of novel supramolecular polymer hydrogels is of particular interest as these materials possess speci c non-covalent and dynamic binding motifs, which can be addressed by external stimuli and are tuned by modifying the architecture and density of cross-links
Numerous investigations on supramolecular polymer hydrogels based on cyclodextrin (CD) inclusion complexes have been reported with various structural designs of CD and guest-functionalized polymers.[16,17,18,19,20,21,22,23,24]
Summary
A carbohydrate-based hydrogel containing vesicles as responsive non-covalent cross-linkers Himmelein, Sabine; Lewe, Vanessa; Stuart, Marc C. Citation for published version (APA): Himmelein, S., Lewe, V., Stuart, M. A carbohydrate-based hydrogel containing vesicles as responsive non-covalent cross-linkers. More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverneamendment. Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. For technical reasons the number of authors shown on this cover page is limited to 10 maximum
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