Abstract
Bone morphogenetic protein 5 ( BMP5) gene was suggested to be a potential positional candidate gene for fatness trait QTLs on SSC7. Here by comparative sequencing of BMP5 gene in Meishan (MS) and Large White (LW) pigs, one SNP *131C > T in 3′ un-translated region was detected. Association analysis results in 322 LW × MS F 2 pigs showed that CC pigs had thinner back fatness and heavier ham than TC ( P < 0.05 or P < 0.1), and had a higher fat percentage and a lower lean meat percentage ( P < 0.1) than TT. Moreover, this C/T transition was predicted to alter BMP5 interaction with let-7c and miR- 184 by using RNA22 and RNAhybrid. The negative expression of BMP5 gene with let-7c and miR-184 detected from miRNAs overexpression in swine fibroblast, indicating these 2 miRNAs might participate in the translational inhibition of BMP5 gene. Overall, SNP *131C > T might be a good marker for fatness traits.
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