Abstract
We propose an ionic conductance model that simulates fast rhythmic bursts in a single compartment neuron. In this modeling, the essential point is that Ca 2+-dependent cationic current, whose reversal potential is approximately −45 mV , plays a key role for generating the depolarizing afterpotential (DAP) and the doublet/triplet firing. For the calcium dynamics, the kinetics of the extrusion and the chelation of intracellular free Ca 2+ with Ca 2+-pump and buffering proteins is taken into account. The resulting model quite accurately predicts the experimentally observed natural pattern of the chattering behavior.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
