Abstract
Here we report a brushed magnetic microbeads (BMBs) carrier with host-guest structures for enhancing bio-detection performance in beads-based flow cytometry (FCM). The micro-sized MBs are employed as host spheres and the nano-sized spherical polyelectrolyte brushes (SPBs) are utilized as guest particles to achieve the covalent assembly of SPBs on MBs (that is BMBs). Our proposed BMBs carrier exhibits a remarkable signal to noise improvement of approximately 8–9 times in beads-based immunoassay on FCM compared to conventional MBs via preserving capture antibodies’ activity and reducing detection antibodies’ nonspecific adsorption. This study demonstrates the promising potential of our developed BMBs carrier for beads-based flow cytometry.
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