A brief review on Triazole and its Pharmacological Application

Kuldeep T Padhyar

doi:10.47191/ijcsrr/v5-i1-25

Abstract

The triazole core is one of the most imperative and well known heterocycles which is composed of nitrogen atom which forms natural products with medicinal claims. Triazole moiety is present as a principal structural component in the drug categories such as antimicrobial, anti-inflammatory, analgesic, antineoplastic, antimalarial, antiviral, antihypertensive, local anaesthetic, antianxiety, anti-Parkinson′s, antidepressant, antioxidant, antihistaminic, antitubercular, antidiabetic etc. The broad and potent activity of triazole and their derivatives has established them as pharmacologically significant platforms. The elementary heterocyclic rings present in the numerous medicinal mediators are 1,2,3-triazole and 1,2,4-triazole. A huge capacity of investigations has been approved on triazole and their results, which has proved the pharmacological status of this heterocyclic core. The current paper is an try to review the pharmacological activities reported for triazole derivatives in the current literature with an apprise of current research discoveries on this nuclei.

Highlights

Triazole is acknowledged as pyrrodiazole is single class of organic heterocyclic complexes containing a five-membered Di unsaturated ring assembly composed of three N atoms and two C atoms at non-adjacent positions
Queiroz et al [15] have study the Semi-synthesis of β-keto-1,2,3-triazole derivatives from ethinylestradiol and the synthesized compound shows cytotoxic activity
Muhamad Mustafa et al [18] have synthesized a potent combretastatin A-4 analogs containing 1,2,4-triazole which carried out antiproliferative, anti-tubulin activity, and docking study

Summary

Introduction

Triazole is acknowledged as pyrrodiazole is single class of organic heterocyclic complexes containing a five-membered Di unsaturated ring assembly composed of three N atoms and two C atoms at non-adjacent positions. Zhe Zhang et al [5] present work describes synthesis and biological activities of novel pleuromutilin derivatives with a substituted triazole moiety as potent antibacterial agents. Nashwa Hafez Zaher et al [6] existing work describes synthesis and molecular docking of novel triazole derivatives as potential CoV helicase inhibitors. Thanh et al [8] present work describes Efficient click chemistry towards novel 1H-1,2,3-triazole-tethered 4-H chromene D-glucose conjugates: Design, synthesis and evaluation of in vitro antibacterial, MRSA and antifungal activitie

Results

Conclusion