A Brief Review on Topical Gels as Drug Delivery System

Bipul Rabha,Chinmoy Bhuyan,Dipankar Saha

doi:10.9734/jpri/2021/v33i47a33020

Bipul Rabha, Chinmoy Bhuyan + Show 1 more

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https://doi.org/10.9734/jpri/2021/v33i47a33020

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Abstract

The method of applying prescription dosage forms to the skin for direct treatment of a cutaneous disorder is known as a topical drug delivery system. Topical gels are semisolid dosage forms in which a liquid phase is constrained within a three-dimensional polymeric matrix derived from natural or semi-synthetic sources with high physical or chemical cross-linking. Because of their intermediate behavior between solid and liquid materials, topical gels are an excellent candidate for transdermal drug delivery. Clinical evidence indicates that topical gel is a safe and effective treatment choice for the management of skin-related diseases, especially when used for local action to avoid the side effects of other conventional dosage forms. Gels, cream, ointment, and paste are the most commonly used semi-solid formulations for topical drug delivery. Gels are colloids in which the liquid medium has thickened to the extent that it behaves like a solid. Since topical gel formulations are less greasy and can be quickly removed from the skin, they offer better drug delivery. In comparison to cream, ointment, and paste, gel formulations have improved application properties and consistency. This article aims to review the principles and recent developments in topical gels, including classification, methods of preparation, applications, and so on.

Highlights

Research has made it possible to treat, prevent and eradicate many of these diseases that plague man [1]
Gels have a wide range of uses, from food additives to pharmaceuticals and medicinal applications, due to this property [3,4]
PH Measurement: pH of gel formulation is determined by using a digital pH meter. 1 gm of gel is dissolved in 100ml of distilled water and stored for two hours

Summary

Introduction

Research has made it possible to treat, prevent and eradicate many of these diseases that plague man [1]. Has progressed a great deal in the past few decades. The treatment of diseases via biomolecules such as drugs, proteins, etc. These carriers allow for the release of drugs in sites that were previously inaccessible [1,2]. Natural, and synthetic materials have all been used to make these carriers over the years. Biocompatibility, and durability were all taken into account, resulting in the use of three-dimensional matrices as carrier materials. The term "gels" refers to a group of materials. Gels have a wide range of uses, from food additives to pharmaceuticals and medicinal applications, due to this property [3,4]

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