Abstract
A brief review on Drug-induced hepatotoxicity: Use of hepatoprotective agents - IJCAAP- Print ISSN No: - 2581-5555 Online ISSN No:- 2456-9542 Article DOI No:- 10.18231/j.ijcaap.2020.004, IP International Journal of Comprehensive and Advanced Pharmacology-IP Int J Compr Adv Pharmacol
Highlights
Adverse Drug Reactions (ADRs) are common and constitute major health problem
The parent drug administered is often responsible for producing the desired therapeutic effect; but the adverse events or the toxic effects produced by the drugs are not just related to the parent compound where the metabolites of the drug produced by the enzymes, light or by the Reactive Oxygen Species (ROS), contribute to the damage caused, as seen in the toxic reactive intermediate - a metabolite of acetaminophen which being highly reactive binds to nucleophiles such as glutathione (GSH) and in cases when the glutathione is depleted, binds to the cellular macromolecules, causing the death of liver cells.[1,2,3]
Importance of drug-induced liver injury the present review study was done by extensive literature search using the keywords such as, Adverse Drug Reactions, Drug-Induced Hepatotoxicity, Hepatoprotectives, Hepatotoxicity, Liver Injury, Methionine and N-Acetyl –L– Cysteine
Summary
Adverse Drug Reactions (ADRs) are common and constitute major health problem. Liver being the major organ involved in the systemic detoxification and deposition of endogenous and exogenous substances; the disease of liver are considered to be serious health disorders, continues to be one of the major cause of morbidity and mortality rate which encompasses a clinical histological spectrum. Looking to the various studies[3,6,7,8,9,10,11] it is understood that hepatotoxicity which is known as Drug-Induced Liver Injury (DILI), is of major concern owing to the ever increasing number of new drug molecules introduced into the pharmaceutical market for treatment of various diseases.
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