Abstract

HIV associated neurocognitive disorder (HAND) is highly prevalent in sub-Saharan Africa, and with the support of anti-retroviral treatment, more people are able to remain in the workplace. However, the potential for HAND to affect the individual health and safety of employees is substantial. Formal assessment of HAND is resource intensive, and often outside the capability of smaller organisations which offers occupational health support. This paper describes a protocol for a brief neurocognitive assessment for HAND in low resourced occupational health settings. The paper firstly describes the development – following seven guidelines – of a relatively inexpensive and relatively brief protocol to assess for the presence of HAND, in a South African low resourced occupational health setting. The resultant Brief Neurocognitive Assessment (BNCA) is then described in detail, as well as the larger process within which it is administered. Further, neuropsychological data from the first 60 completed assessments are presented, together with a discussion of its adherence to the guidelines set out prior to its development. A number of neuropsychological markers appeared to differentiate between the normal and mild impairment groups, suggesting that the BNCA may be useful in identifying individuals with potential problematic neurocognitive functioning. A brief assessment such as the BNCA could provide meaningful recommendations regarding both clinical management and workplace utilisation to employers. It would be important that proper processes (e.g. conditions for assessments, appropriate follow up procedures, confidentiality, and so forth) are imposed and maintained. Finally, this paper invite discussion for improved management of HAND assessment in the workplace.

Highlights

  • This paper aims to describe a protocol for a brief neurocognitive assessment for HIV-associated neurocognitive disorder (HAND) in low resourced occupational health settings

  • This model provides for three progressive conditions of HIV-associated neurocognitive decline, namely asymptomatic neurocognitive impairment (ANI), mild neurocognitive disorder (MND) and HIV-associated dementia (HAD)

  • HAND remains highly prevalent, with global prevalence reported from 30-50% in people living with HIV and AIDS (PLWHA), depending on disease stage and the use of anti-retroviral treatment (ART)

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Summary

Introduction

This paper aims to describe a protocol for a brief neurocognitive assessment for HIV-associated neurocognitive disorder (HAND) in low resourced occupational health settings. HAND status is currently determined using the Frascati criteria, which requires neuropsychological (NP) scores across seven domains to be compared to normative data using standard deviations as indicators of impairment [1]. This model provides for three progressive conditions of HIV-associated neurocognitive decline, namely asymptomatic neurocognitive impairment (ANI), mild neurocognitive disorder (MND) and HIV-associated dementia (HAD). In sub-Saharan Africa (SSA), where there is high prevalence of HIV itself, HAND prevalence rates ranging from 39-76% have been reported for general clinical

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