A brief literature review and own clinical experience in prophylaxis of oral mucositis in children using low level laser therapy

Sergey Moskvin,Elena Lukash,Leonid Gusev,Denis Pritiko,Elena Sergeenko

doi:10.1051/bmdcn/2019090101

Abstract

Objective: The article describes the experience of clinical application of low level laser therapy in pediatric oncology for the prevention and treatment of chemotherapy complications such as oral mucositis.Background: For this purpose, for the first time in the world non-invasive laser blood illumination is used on the sinocarotid zone (on the projection of the common carotid artery symmetrically) and popliteal fossa in order to stimulate the phagocytic activity of leukocytes.Methods: 25 children with different oncological diseases were given non-invasive laser blood illumination treatment (904 nm, pulse mode, 100 ns, 50-150 Hz, 5-7 W, 4 cm2, 1-2 minutes daily per each procedure) 1-3 days before the beginning of chemotherapy. For the objectification of the results of treatment, the phagocytic activity of leukocytes was evaluated.Results: None of the children who underwent low level laser therapy course had any complications and no cases of oral mucositis developed.Conclusions: Clinical experience has shown high efficacy and safety of low level laser therapy aimed at preventing the development of complications of chemotherapy, primarily oral mucositis, and stimulating the phagocytic activity of leukocytes.

Highlights

Oral mucositis (OM) - erosive and ulcerative lesions of the mucous membrane in the mouth, pharynx, esophagus, and in the whole gastrointestinal tract in adults and children, as a result of chemotherapy, radiation therapy of the head and neck area, as well as stem cell transplantation [1, 2]
In the group consisting of 25 patients, 47 procedures of non-invasive laser blood illumination technique (NLBI) were performed, and OM had developed in no cases, or other complications were recorded
Clinical experience has shown high efficacy and safety of laser light therapy aimed at preventing the development of complications of chemotherapy, primarily oral mucositis, and stimulating the phagocytic activity of leukocytes

Summary

Introduction

Oral mucositis (OM) - erosive and ulcerative lesions of the mucous membrane in the mouth, pharynx, esophagus, and in the whole gastrointestinal tract in adults and children, as a result of chemotherapy, radiation therapy of the head and neck area, as well as stem cell transplantation [1, 2]. J.M. Bjordal et al (2011) [10] gives nearly exact recommendations of parameters of laser therapeutic techniques, but since there is little understanding of the mechanisms of the biological action of low-intensity laser light (LILL), the choice of wavelength and operating mode of the laser recommend by manufacturers of the apparatus does not provide a satisfactory result. Bjordal et al (2011) [10] gives nearly exact recommendations of parameters of laser therapeutic techniques, but since there is little understanding of the mechanisms of the biological action of low-intensity laser light (LILL), the choice of wavelength and operating mode of the laser recommend by manufacturers of the apparatus does not provide a satisfactory result This raises quite justifiable doubts about the reproducibility of the data obtained [11]. The problem of misunderstanding the primary mechanisms of the biomodular action of LILL is obvious, and can often be associated with "wandering in the dark" in search for the optimal parameters of low level laser therapy methods, which was manifested in the joint work of our Dutch colleagues [12, 13]

Results

Discussion

Conclusion