A Brief Introduction to New NIT Nitroxoids

Abstract

Before 2021, it is estimated that there may be 9.96 million new cancer deaths and new metastasis cases per year globally. It is generally believed that chemotherapy drugs used for anticancer drugs have large toxic side effects, easy to cause tissue resistance, low selectivity, and not significant therapeutic effect. Because of the special stereoscopic structure and lipophilicity of caged compounds, some of their derivatives often have some more biological pharmacological activities, such as antiviral, enhancing cellular immunity, and anti-tumor activity. Researchers have found that a cage compound with good lipophilicity can be used as a structural unit to develop new drugs with good selectivity, high efficiency and low toxicity. NIT nitroxide radicals have excellent antitumor activity. This article reviews the design and synthesis of novel nitroxide compounds by introducing cage structure into NIT nitroxide radicals.