A Brief, Fully Automated Neurocognitive Training Intervention Extends the Antidepressant Effect of a Single Ketamine Infusion

Abstract

Intravenous ketamine, which displays rapid antidepressant properties, is posited to reverse depression by rapidly enhancing neuroplasticity. We posited that ketamine would provide a clinical window of opportunity in which to introduce automated neurocognitive training techniques to consolidate adaptive forms of cognitive processing (specifically, positive implicit representations of self) while neuroplasticity remains high.