Abstract
Chinese medicine (CM) is gaining popularity in recent years, prompting researchers’ and clinicians’ interest and effort into the makings and effects of it, especially after the announcement of World Health Organisation’s incorporation of CM into the mainstream medical compendium, followed by the promising outcome brought about by the implementation of CM in the recent pandemic. Individual herb has complex properties, coming from its pharmacological properties and the Chinese medical principles of organ-directed, taste and dynamic orientational behaviours. The use of individual herb in CM prescription is rare. Formula prescriptions predominantly consist of two ingredients or more. To fully reveal the effects of CM is a great challenge. The compound reaction of various herbs, the absorption and utility rate by the body, uniqueness of individual physique, sub-types of pathological behaviours and time-line progression at the healing process add on to the complexity of understanding the full effect of CM. Various theories such as pathophysiology guidance, pharmacokinetic-pharmacodynamic compatibility method, and Global Systems Biology for Integrative Genomics, Proteomics and Metabolomics, which interactively provide a more comprehensive and greater in-depth understanding, together with the consideration of development timeline, may shed more light to revealing the full picture of the effects of compatibility prescription.
Highlights
Background of Compatibility ofHerbs in a FormularWith thousands of years of application and experiences, traditional Chinese medicine (TCM) has been widely used in the modern society on disease prevention, treatment and health care
Compatibility herbs is a special feature of syndrome differentiation, which is a unique methodology of TCM diagnosis
Due to the nature of Chinese herbal medicine, and its use in combination with various components, knowing its main efficacy for a particular condition is attainable, but to fully understand all relationships and cause-and-effects it has on the body remains a great challenge
Summary
Background of Compatibility ofHerbs in a FormularWith thousands of years of application and experiences, traditional Chinese medicine (TCM) has been widely used in the modern society on disease prevention, treatment and health care. From the recognition of Nobel Laureate Tu YouYou’s discovery on artemisinin treating malaria in 20151, to the most recent World Health Organization’s recognition of traditional medicine in its influential global medical compendium[2], interest in traditional Chinese medicine (TCM) has reached a new height. It is to be noted, that artemisinin is an extract from the plant Artemisia apiacea, which can at most be considered an herbal medicine (or herbal extract) but falls short of being classified as CM. J Human Clin Gen (2020);2(2):[21,22,23,24,25,26,27]
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