Abstract
Unlike mammals, zebrafish are capable to regenerate many of their organs, however, the response of tissue damage varies across tissues. Understanding the molecular mechanism behind the robust regenerative capacity in a model organism may help to identify and develop novel treatment strategies for mammals (including humans). Hence, we systematically analyzed the current literature on the proteome profile collected from different regenerated zebrafish tissues. Our analyses underlining that several proteins and protein families responsible as a component of cytoskeleton and structure, protein synthesis and degradation, cell cycle control, and energy metabolism were frequently identified. Moreover, target proteins responsible for the initiation of the regeneration process, such as inflammation and immune response were less frequently detected. This highlights the limitation of previous proteomic analysis and suggested a more sensitive modern proteomics analysis is needed to unfold the mechanism. This brief report provides a list of target proteins with predicted functions that could be useful for further biological studies.
Highlights
Regeneration is a process by which an organism restores or replaces damaged tissues through a complex mechanism, resulting in the same morphological and physiological properties as the undamaged one [1,2]
To understand more detailed information into the role of the identified proteins required during zebrafish regeneration, we looked at the biological processes and functions of all differentially expressed proteins in each experimental study
Proteomic alterations of the included studies were evaluated by 2-DiGE (Two-dimensional difference gel electrophoresis, n = 3) [12,14,15], LC-MS/MS [1,11,16], and SILAC [3,13]
Summary
Regeneration is a process by which an organism restores or replaces damaged tissues through a complex mechanism, resulting in the same morphological and physiological properties as the undamaged one [1,2]. Several tissues such as skin and the gut epithelia exhibit a highly cellular turnover. Neurons and cardiomyocytes are not completely restored [2,3]. Limited regenerative capacity observed in mammals is believed to contribute to a variety of diseases, such as neurodegenerative disorders and heart failure. Regeneration in mammalian cells typically leads to scarring [4]. This possibly due to the imbalance between regeneration and scar formation [5,6]
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