Abstract
It has been recently suggested that bradykinin (BK) may act as a cardioprotectve agent. In the present investigation, we evaluated the effects of captopril, an angiotensin-converting enzyme inhibitor (ACEI), and kinin B 2 receptor antagonist, d-Arg-[Hyp3- d-Phe7]-BK, on the duration of survival after acute coronary artery ligation for 15 min in spontaneously hypertensive rats (SHR). The captopril treatment (16 and 32 ug/kg, i.v.) resulted in a significant ( p < 0.05) increase in survival time of SHR as compared with saline-treated control SHR. Kinin B 2 receptors antagonist (4 ug/kg, i.v.) pretreatment abolished ( p > 0.05) the beneficial effect of captopril on survival time as compared to saline-treated control SHR. Both the ligation of coronary artery and captopril treatment resulted in a significant ( p < 0.001) fall in systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) of SHR as compared to the saline-treated control SHR. In addition, captopril administration caused a significant ( p < 0.05) fall in the SBP, DBP and HR of SHR before ligation of the coronary artery (preligation). However, there was no significance ( p > 0.05) in SBP, DBP and HR between saline- and kinin B 2 receptor antagonist plus captopril-treated SHR during preligation. These finding might indicate that captopril possesses a cardioprotective property as demonstrated by increased in survival time of SHR. This beneficial effect of captopril is mediated via the kinin B 2 receptor pathway because kinin B 2 receptor antagonist pretreatment blocked the captopril-induced increase in survival time of SHR.
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