A Bootstrap Approach for Testing Marginal Independence Between Two Categorical Variables When Subjects Have Repeated Responses

Abstract

To assess independence in two-way contingency tables, the Pearson chi-square test or Fisher’s exact test are typically used. These tests assume that each subject contributes at most one count to only one table cell (e.g., sex versus blood type). In other situations, each subject may have more than one count contributing to the table and these counts may occur in different cells of the table. One may wish to test independence, adjusting for the within-subject correlation. We provide a simple nonparametric bootstrap approach and assess its performance through simulation studies. The method is illustrated on subjects with multiple mental health presentations to Emergency Departments.