Abstract
Heart muscle cells die en masse after injury, yet the adult mammalian heart retains little capacity to regenerate them. Regulatory microRNA sequences may stimulate self-renewal of these muscle cells. See Article p.376 The mammalian heart has a poor capacity to regenerate, with the ability of cardiomyocytes to proliferate disappearing soon after birth. In this study, Mauro Giacca and colleagues screened a synthetic microRNA (miRNA) library of human origin for the ability to induce cardiomyocyte proliferation, with aim of identifying potential human therapeutics. Forty miRNAs strongly increased both DNA synthesis and cytokinesis in rodent cardiomyocytes. The two most potent, hsa-miR-590 and hsa-miR-199a, were tested further and shown to induce cardiac regeneration after myocardial infarction in mice. In vivo treatment with these miRNAs led to almost complete and stable recovery of cardiac function.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
