Abstract
Background: Blood brain barrier (BBB) dysfunction has been implicated in many illnesses such as stroke, traumatic brain injury, Parkinson's disease, Alzheimer's disease, schizophrenia, multiple sclerosis, as well as more uncommon conditions such as chronic Lyme disease, chronic fatigue syndrome, Gulf War-related illness, and HIV dementia. Investigations on BBB neurophysiology are limited by nonavailability of disease-specific human brain microvessel endothelial cells (HBMECs) for in vitro culture experiments, despite routine availability of normal, non-disease related HBMECs.
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