Abstract
A new bis(pyridine-2-ylmethyl)amine derivative (1) was synthesized as a colorimetric and fluorescent chemosensor for metal ions. Experimental results indicate that 1 displays significant colorimetric and fluorescent changes upon binding of Cu2+. Since 1 has a high water solubility as well as good cell-permeability, it successfully applied to detect the presence of Cu2+ ion in HepG2 cells in culture medium. Thus, 1 can be used as a potential Cu2+ chemosensor in aqueous solution and mammalian cells. Further, the fluorescence behavior of 1 upon Cu2+ binding was well explained by our quantum calculation based on electronic structure.
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