A Biphasic Fluid-Structure Interaction Model of Backflow During Infusion Into Agarose Gel.

Abstract

The efficacy of convection-enhanced delivery as a technique to treat disorders of the central nervous system is limited by backflow, in which the infused fluid flows backwards along surface of the catheter rather than towards the targeted area. In order to improve treatment protocols, finite element models of backflow have been developed to understand the underlying physics. Garcia et al. (Journal of Computational and Nonlinear Dynamics, 8:011017, 2013) presented a finite element model that accounted for the flow in the annular gap that develops between the tissue and the outer surface of the catheter by using a layer of biphasic elements with a formula for the axial hydraulic conductivity to represent annular Poiseuille flow. In this study, we present a generalization of that model using fluid-FSI and biphasic-FSI elements that are recently available in FEBio. We demonstrate that our model of a 0.98-mm-radius catheter is able to reproduce experimental backflow lengths and maximum fluid pressures for infusions into a brain tissue surrogate and that it agrees well with the previous model by Garcia et al. (2013). The model predicts that the backflow length and the total amount of flow into the hemispherical region forward of the catheter tip is comparable for two different catheter sizes, albeit at a higher fluid pressure for the smaller catheter. This biphasic-FSI model has the potential to be extended to a stepped catheter geometry, which has been shown in experiments to be successful in controlling backflow.