Abstract
A novel class of octopamine agonists, the 2-aminooxazolines, were discovered by in vitro receptor screening in insects. A very active member of this class of octopamine agonist (2-(4-chloro- o-toluidino)-2-oxazoline) was synthesized and found to possess insecticidal/acaricidal properties similar to those seen with the formamidine pesticide, chlordimeform, which is known to act as an octopamine agonist. In addition to the direct toxic effects on insects and acarids, the characteristic symptomology of poisoning associated with octopaminergic pesticides was observed.
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