Abstract
In silico energy modeling has shown that guanine-rich regions of certain nucleic acids are capable of forming secondary structures known as G-quadruplexes. These structures are subject to unique protein binding and therefore partake in gene regulation by mediating translation of messenger RNA (mRNA). Such regulation suggests that G-quadruplex-containing mRNAs may play a role in the development of certain genetic diseases. We have selected a guanine-rich portion of the mouse cyclin-dependent kinase 5 regulatory subunit 2 (CDK5R2) mRNA 3’ untranslated region for the study of these regulatory G-quadruplexes, as this gene has been implicated in the pathogenesis of a particular inherited disorder, fragile X syndrome (FXS).
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
