A biomimetic study of aliphatic and aromatic dicarboxylic acids engineered β-CD targeted for intestinal maladies

Abstract

Presently, biomaterials are extensively used for biomedical applications such as drug delivery. In-vitro simulation studies provide preliminary insights about the molecular interaction of synthesized biomaterials in the body. In the present work, β-Cyclodextrin materials with succinic acid and phthalic acid as cross linkers exhibited sustained release of the drug, curcumin, during biomimetic screening studies. Fourier transform infrared spectroscopy(FTIR), 1H-NMR,particle size analysis, scanning electron microscopy (SEM) and X-ray diffraction (XRD) studies were used for the physiochemical characterization of the polymers. The effect of aliphatic and aromatic di-carboxylic acids crosslinking agents on binding of curcumin was studied experimentally and computationally. In-vitro release studies were carried out under simulated gastro-intestinal conditions (pH 1.2 HCl buffer for gastric environment, phosphate buffer of pH 6.8 for duodenum and phosphate buffer of pH 7.4 for intestinal conditions at 37 °C). Sustained drug release was also verified by time dependent anti-inflammatory and anti-cathepsin studies. The results indicated these synthesized biomaterials can be used for intestinal delivery of curcumin.