Abstract
Biomicrofluidic Models Biomicrofluidic models allow nanoparticle-cellular interactions to be studied under physiological flow conditions. Investigating nanoparticle biophysicochemical properties in models that resemble disease can provide valuable information about the nano-bio interface. By screening nanoparticles dynamically against a developed dysfunctional-endothelium-on chip model, Nazila Kamaly and co-workers show in article number 2100092 that nanoparticle size is a dominant factor beyond targeting ligands. Furthermore, tight junction disruption can be restored by the inflammation resolving mediator Annexin A1.
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