Abstract
BackgroundUndergraduate biomedical engineering (BME) students interested in pursuing a career in research and development of medical or physiological monitoring devices require a strong foundation in biosignal analysis as well as physiological theory. Applied learning approaches are reported to be effective for reinforcing physiological coursework; therefore, we propose a new laboratory protocol for BME undergraduate physiology courses that integrates both neural engineering and physiological concepts to explore involuntary skeletal muscle reflexes. The protocol consists of two sections: the first focuses on recruiting soleus motor units through transcutaneous electrical nerve stimulation (TENS), while the second focuses on exploring the natural stretch reflex with and without the Jendrassik maneuver. In this case study, third-year biomedical engineering students collected electromyographic (EMG) activity of skeletal muscle contractions in response to peripheral nerve stimulation using a BioRadio Wireless Physiology Monitor system and analyzed the corresponding signal parameters (latency and amplitude) using the MATLAB platform.Results/protocol validationElectrical tibial nerve stimulation successfully recruited M-waves in all 8 student participants and F-waves in three student participants. The students used this data to learn about orthodromic and antidromic motor fiber activation as well as estimate the neural response latency and amplitude. With the stretch reflex, students were able to collect distinct signals corresponding to the tendon strike and motor response. From this, they were able to estimate the sensorimotor conduction velocity. Additionally, a significant increase in the stretch reflex EMG amplitude response was observed when using the Jendrassik maneuver during the knee-jerk response. A student exit survey on the laboratory experience reported that the class found the module engaging and helpful for reinforcing physiological course concepts.ConclusionThis newly developed protocol not only allows BME students to explore physiological responses using natural and electrically-induced involuntary reflexes, but demonstrates that budget-friendly commercially available devices are capable of eliciting and measuring involuntary reflexes in an engaging manner. Despite some limitations caused by the equipment and students’ lack of signal processing experience, this new laboratory protocol provides a robust framework for integrating engineering and physiology in an applied approach for BME students to learn about involuntary reflexes, neurophysiology, and neural engineering.
Highlights
Despite diversity across different undergraduate biomedical engineering (BME) curricula, most programs include physiology as a core part of the student learning experience [1] upon recognition of its importance in promoting interdisciplinary engagement [2]
Despite some limitations caused by the equipment and students’ lack of signal processing experience, this new laboratory protocol provides a robust framework for integrating engineering and physiology in an applied approach for BME students to learn about involuntary reflexes, neurophysiology, and neural engineering
transcutaneous electrical nerve stimulation (TENS) EMG response The EMG response to electrical stimulation using the TENS device was collected in eight student participants
Summary
Despite diversity across different undergraduate biomedical engineering (BME) curricula, most programs include physiology as a core part of the student learning experience [1] upon recognition of its importance in promoting interdisciplinary engagement [2]. Beyond understanding fundamental anatomical and physiological concepts, it is important for BME students interested in pursuing graduate education or a professional career designing and developing medical devices to learn effective acquisition of biosignals [3], because these responses can be monitored and measured to provide real-time feedback regarding system function. It is critical to provide opportunities for our students to develop skills in biosignal data acquisition and analysis, with strong ability to translate outcomes to physiological function. In the context of biosignal study, lack of practical experience restricts the opportunity for BME students to merge data outcomes with physiological concepts and translate them into tangible applications. Undergraduate biomedical engineering (BME) students interested in pursuing a career in research and development of medical or physiological monitoring devices require a strong foundation in biosignal analysis as well as physiological theory. Third-year biomedical engineering students collected electromyographic (EMG) activity of skeletal muscle contractions in response to peripheral nerve stimulation using a BioRadio Wireless Physiology Monitor system and analyzed the corresponding signal parameters (latency and amplitude) using the MATLAB platform
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