A Biomedical Application by Using Optimal Fuzzy Sliding-Mode Control

Abstract

The development of biochips is a major thrust of the rapidly growing biotechnology industry. Research on biomedical or biochemical analysis miniaturization and integration has made explosive progress by using biochips recently. For example, capillary electrophoresis (CE), sample preconcentration, genomic DNA extraction, and DNA hybridization have been successfully miniaturized and operated in a single-step chip. However, there is still a considerable technical challenge in integrating these procedures into a multiple-step system. In biometric and biomedical applications, the special transporting mechanism must be designed for the μTAS (micro total analysis system) to move samples and reagents through the microchannels that connect the unit procedure components in the system. Therefore, an important issue for this miniaturization and integration is microfluid management technique, i.e., microfluid transportation, metering, and mixing. This charter introduced a method to achieve the microfluidic manipulated implementation on biochip system with a pneumatic pumping actuator and a feedbacksignal flowmeter by using an optimal fuzzy sliding-mode control (OFSMC) design based on the 8051 microprocessor. However, the relationships of the pumping mechanisms, the operating conditions of the devices, and the transporting behavior of the multi-component fluids in these channels are quite complicated. Because the main disadvantages of the mechanical valves utilized moving parts are the complexity and expense of fabrication, and the fragility of the components. Therefore, a novel recursively-structured apparatus of valveless microfluid manipulating method based on a pneumatic pumping mechanism has been utilized in this study. The working principle of this pumping design on this device should not directly relate to the nature of the fluid components. The driving force acting on the microliquid drop in the microchannel of this device is based on the pneumatic pumping which is induced by a blowing airflow. Furthermore, the pneumatic pumping actuator should be independent of the actuation responsible for the biochemical analysis on the chip system, so the contamination of pneumatic pumping source can be avoided. The total biochip mechanism consists of an external pneumatic actuator and an on-chip planar structure for airflow reception. In order to achieve microfluidic manipulation in the microchannel of the biochip system, pneumatic pumping controller plays an important role. Therefore, a design of the controller