Abstract
A biomechanical study of the role of sitagliptin on the bone characteristics of diabetic rats
Highlights
Diabetes mellitus is a disease which increases the blood glucose levels of the patient
An experimental protocol is described aiming to explore the influence of Type 2 Diabetes Mellitus on the biomechanical response of the bone tissue and, to quantify the potential beneficial role of a pharmaceutical treatment, based on sitagliptin, a diabetes drug that increases the levels of natural substances called incretins
The present study focuses on Type 2 Diabetes Mellitus (T2DM), taking into account that T2DM patients are the majority (>90%) of diabetic patients, where inadequate insulin is produced, less sugar is moved into cells and blood glucose levels increase
Summary
Diabetes mellitus is a disease which increases the blood glucose levels of the patient. Glucose-dependent Insulinotropic Polypeptide (GIP) and Glucagon-Like Peptide-1 (GLP-1) are known incretin hormones from the upper (GIP, K cells) and lower (GLP-1, L cells) gut [1]. The main challenge of the study was the accurate determination of the geometrical features of the fractured cross-section, in an attempt to avoid adopting simplifying assumptions, like, for example, to consider the cross-section as a circular or elliptic ring In this direction, the approach suggested by Biewener [8] (permitting determination of the area, the centroid, the second moment of area and the coordinates of the points with the maximum distance from the neutral plane), was adopted and developed further, for the calculation of the fracture stress. The study enlightens interesting aspects of the role of T2DM and sitagliptin on the quality of the bone tissue of diabetes patients, which are not always in line with the respective ones of already published studies
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