Abstract
1* Abstract Peptide - Peptide Nucleic Acid (PNA) conjugates are known for their antibacterial effects on several pathogens. Here we designed five PNA-peptide conjugates that consist of sequences originating from conservative sequences of 16S ribosomal RNA (rRNA) from hundreds of different bacterial species. Their antibacterial effects were tested on E. coli K12 and Klebsiella pneumoniae. The result shows the sequence-dependent antibacterial or bactericidal effects of the designed peptide-PNA conjugates. We also developed a bioinformatics tool and examined any possible off-target effects of the peptide-PNA we designed. Using this tool, we also predicted the least off-target sequences for further studies. Designing peptide-PNAs utilizing conservative 16S rRNA sequences may pave a way to developing broad-spectrum ribosomal antibiotics fighting life-threatening, drug-resistant infections.
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