Nanomedicine | VOL. 15
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A bioglass sustained-release scaffold with ECM-like structure for enhanced diabetic wound healing

Publication Date Oct 1, 2020

Abstract

Aim: To develop an effective strategy for increasing angiogenesis at diabetic wound sites and thereby accelerating wound healing. Materials & methods: A micropatterned nanofibrous scaffold with bioglass nanoparticles encapsulated inside coaxial fibers was prepared by electrospinning. Results: Si ions could be released in a sustained manner from the scaffolds. The hierarchical micro-/nano-structure of the scaffold was found to act as a temporary extracellular matrix to promote endothelial cell adhesion and growth. The scaffold greatly improved angiogenesis and collagen deposition at the wound site, which shortened the healing period of diabetic wounds. Conclusion: This study provides a promising therapeutic option for chronic diabetic wounds with improved angiogenesis.

Concepts

Diabetic Wound Hierarchical Micro Accelerating Wound Healing Wound Site Si Ions Collagen Deposition Sustained Manner Temporary Matrix Wound Healing Endothelial Cell Growth

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