A Bioelectronic Platform Modulates pH in Biologically Relevant Conditions.

Xenofon Strakosas,John Selberg,Noah Christie,Adah Almutairi,Peng‐Hao Hsu,Marco Rolandi,Xiaolin Zhang

doi:10.1002/advs.201800935

Abstract

Bioelectronic devices that modulate pH can affect critical biological processes including enzymatic activity, oxidative phosphorylation, and neuronal excitability. A major challenge in controlling pH is the high buffering capacity of many biological media. To overcome this challenge, devices need to be able to store and deliver a large number of protons on demand. Here, a bioelectronic modulator that controls pH using palladium nanoparticles contacts with high surface area as a proton storage medium is developed. Reversible electronically triggered acidosis (low pH) and alkalosis (high pH) in physiologically relevant buffer conditions are achieved. As a proof of principle, this new platform is used to control the degradation and fluorescence of acid sensitive polymeric microparticles loaded with a pH sensitive fluorescent dye.

Highlights

Bioelectronic devices that modulate phosphorylation.[19]. The H+ concentration (pH) can affect critical biological processes expression,[22] and is indicative of healthy cell function.[23] phosphorylation.[19] The H+ concentration (pH) regulation in the cenincluding enzymatic activity, oxidative phosphorylation, and neuronal excittral nervous system maintains healthy ability
Numerous diagnostic sen- alkalosis and increase pH, a bioelectronic device needs to spesors exist including for glucose,[1,2] lactate,[3] neurotransmitters,[4] cifically absorb H+ ions without changing the concentration of electrophysiological measurements,[5,6] and barrier tissue integ- other ions in solution
Electroceutical devices for treatment of disease include cifically transfer H+ to and from solution and proton conducting metal electrodes implanted in the brain to stimulate damaged polymers exploiting the specific and reversible Pd/palladium neurons,[9–11] organic electronic devices that electrophoretically deliver small ions (K+, Ca2+) and neurohydride (PdHx) reaction.[29,30]

Summary

Introduction

Bioelectronic devices that modulate pH can affect critical biological processes expression,[22] and is indicative of healthy cell function.[23] pH regulation in the cenincluding enzymatic activity, oxidative phosphorylation, and neuronal excittral nervous system maintains healthy ability. One electrolyte, consisting of 0.5 m HCl is used as a proton source (reservoir) and is in direct contact with a Pd contact modified with Ag/AgCl. The other electrolyte (target) is a buffer solution in which we induce pH modulation.

Results

Conclusion