Abstract
In this work, a biodegradable linear‐dendritic copolymer composed of methoxypolyethylene glycols (mPEG) and a third generation glycolic acid oligomer based dendron is synthesized. The amphiphilic copolymer can self‐assemble into polymeric micelles in aqueous solution with a low critical micelle concentration (CMC). Hydrophobic doxorubicin (DOX) is incorporated into the micellar core via the dialysis method with a high drug loading content of 21.2%. The drug release result implies that the encapsulated drug can be released rapidly at pH 5.0, due to the hydrolysis of the ester bond resulting in quick disassembly of drug‐loaded micelles. Moreover, the results of fluorescence microscopy imaging and flow cytometry measurements demonstrate that the drug carriers can be internalized and DOX released rapidly from them upon endocytosis. Importantly, this drug delivery system exhibits excellent performance to inhibit cancer cell proliferation. image
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
