Abstract
Here, we report a new method to conjugate nanoparticles with live cells with high efficiency and biocompatibility. Distearoylphosphatidylethanolamine (DSPE)-PEG polymers was first gifted with cyclodextrin and then anchored on the surface of mesenchymal stem cells (MSCs). Then azobenzene derivative (Azo)-modified upconversion nanoparticles were conjugated to cells to construct live cells-based nanoparticle delivery system by host-guest interactions between cyclodextrin and Azo. Owing to free of chemical reactions of the DSPE-anchoring and host-guest interactions process, the conjugating strategy is very biocompatible. In vitro study illustrated that the differentiation potential of stem cells was not affected after anchoring nanoparticles indicating a biocompatible conjugating method for the construction of cell patch.
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