Abstract
An assay for desoxycorticosterone acetate has been developed in which male albino adrenalectomized rats are used as the test animal and a Perkin‐Elmer flame photometer is employed to measure the electrolyte excretion in various six‐hour urine samples. Injections of 5cc. of 0.9 per cent sodium chloride solution and 0.5cc. of 10 per cent potassium chloride solution were given at the same time as the desoxycorticosterone acetate to assure the quantitative accuracy of the assay. An injection of 10 per cent potassium chloride solution seems to make the assay accurate quantitatively within a dose range of 6–50 μg. of desoxycorticosterone acetate, using potassium excretion as the indicator.
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