Abstract
Homogeneous controlled release of active ingredients, avoiding secondary damage of dressing changes would be considerable advance for transcutaneous drug delivery treatment. Here, a bio-degradable, self-stimulated herbal transdermal therapeutic dressing (irritability) driven by multi-ball nimble-rolling triboelectric nanogenerator (mbnr-TENG) is proposed that provided a stable and adjustable triboelectric field for controlling drug release. The mbnr-TENG deliver a periodic triboelectric field of 140 V for herbal dressings by collecting human mechanical energy to enhance transdermal properties of total flavonoids and chlorogenic acid in ss-HTTD by 310% and 147%. Following a therapeutic cycle using ss-HTTD, the secretion of inflammatory factors decreased by 50.35%, and wound healing rate increased by 24.98%, then completely degraded after 10 days. As a new drug delivery system, this work holds great potential in healing massive chronic wound, ss-HTTD is advantageous in controlling drug release, enhancing the activity and the long-term stability of herbal medicines.
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