Abstract
Artificial extracellular matrices (aECMs) are an extension of biomaterials that were developed as in-vitro model environments for tissue cells that mimic the native in vivo target tissues’ structure. This bibliometric analysis evaluated the research productivity regarding aECM based on tissue engineering technology. The Web of Science citation index was examined for articles published from 1990 through 2019 using three distinct aECM-related topic sets. Data were also visualized using network analyses (VOSviewer). Terms related to in-vitro, scaffolds, collagen, hydrogels, and differentiation were reoccurring in the aECM-related literature over time. Publications with terms related to a clinical direction (wound healing, stem cells, artificial skin, in-vivo, and bone regeneration) have steadily increased, as have the number of countries and institutions involved in the artificial extracellular matrix. As progress with 3D scaffolds continues to advance, it will become the most promising technology to provide a therapeutic option to repair or replace damaged tissue.
Highlights
The field of tissue engineering has an extensive range of potential applications in tissue repair and regeneration [1]
Web of Science is a universal scientific citation index used to retrieve scholarly articles and academic literature [41,42]. This bibliometric study analyzed articles related to major journals publishing Artificial extracellular matrices (aECMs) research from 1 January 1990 through 31 December 2019
The output of research related to topic set of our terms search, in the form of publications, increased continuously from 1991 through 2019, resulting in a total of 3801 publications
Summary
The field of tissue engineering has an extensive range of potential applications in tissue repair and regeneration [1]. The role of biomaterials in tissue engineering is to provide support and scaffolding for cell growth, one of the principal factors that determine the success of tissue regeneration [1,2,3]. Tissue engineering is a rapidly advancing field that relies on scaffold biomaterials to provide the appropriate environment to guide the growth of new tissue [7,8,9]. The extracellular matrix (ECM) encompasses the natural surroundings of cells in vivo that maintain structure but regulate many aspects of cell behavior, including cell proliferation, growth, and differentiation [10,11]. The construction of a template ECM surface with the capability of providing a pertinent, in-vitro environment to regulate cellular behavior is a leading approach in biomaterial publications [7,10,18]
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